Last Updated on March 14, 2021

Ladies and gentlemen, we have arrived. After COVID-19 shut down last year’s edition, we will finally be able to watch the NCAA Tournament go down for the first time in two years. Conference tournaments have concluded and the bracket, courtesy of CBS’ Selection Show, is now set. Who will go all the way and take become the winners of the Big Dance this year?

While Gonzaga is the top team in the country heading into the tournament, there are a number of Big Ten and Big 12 squads that can make some noise. Let’s take a look at the odds and lines for the first-round matchups and First Four games along with futures bets for the entire bracket.

As always, the NCAA Tournament is essentially unpredictable. Your bracket could be phenomenal, but there’s no shot you’re able to predict all the cinderella stories along with upsets that occur throughout the entire timeframe in which the tournament is taking place.

There’s only a matter of time before the tournament ultimately commences. First Four games will occur this Thursday before the first round is Friday/Saturday and the second round i Sunday/Monday. The sweet 16 is then the following weekend.

Register with DraftKings Sportsbook and snag 64-1 odds on any of the underdogs in the first round by clicking here.

 

 

2021 NCAA Tournament Odds

Sixteen games on Friday. Sixteen games on Saturday. It’s arguably two of the best sports days of the year, and without further ado, let’s dive into the odds for each of the matchups.

 

Play-in games

No. 16 Norfolk State vs. No. 16 Appalachian State (-2, 136.5)

No. 16 Mount St. Mary’s vs. No. 16 Texas Southern (-1.5, 134.5)

No. 11 Wichita State (-2, 139.5) vs. No. 11 Drake

No. 11 UCLA vs. No. 11 Michigan State (-1.5, 138.5)

 

First-round games

 

EAST REGION

No. 1 Michigan vs. No. 16 Norfolk State/No. 16 Appalachian State

No. 8 LSU (PK) vs. No. 9 St. Bonaventure

No. 5 Colorado (-5.5, 138.5) vs. No. 12 Georgetown

No. 4 Florida State (-11, 146) vs. No. 13 UNC-Greensboro

No. 6 BYU vs. No. 11 Wichita State/No. 11 Drake

No. 3 Texas (-8.5, 140.5) vs. No. 14 Abilene Christian

No. 7 UConn (-2, 131.5) vs. No. 10 Maryland

No. 2 Alabama (-16, 143.5) vs. No. 15 Iona

 

WEST REGION

No. 1 Gonzaga vs. No. 16 Mount St. Mary’s /No. 16 Texas Southern

No. 8 Oklahoma (-2, 141.5) vs. No. 9 Missouri

No. 5 Creighton (-8, 140.5) vs. No. 12 UCSB

No. 4 Virginia (-10.5, 132.5) vs. No. 13 Ohio

No. 6 USC vs. No. 11 UCLA/No. 11 Michigan State

No. 3 Kansas (-11, 140.5) vs. No. 14 Eastern Washington

No. 7 Oregon (-5, 138.5) vs. No. 10 VCU

No. 2 Iowa (-15, 144) vs. No. 15 Grand Canyon

 

SOUTH REGION

No. 1 Baylor (-25.5, 142.5) vs. No. 16 Hartford

No. 8 UNC (-1, 139.5) vs. No. 9 Wisconsin

No. 5 Villanova (-6.5, 137.5) vs. No. 12 Winthrop

No. 4 Purdue (-8, 126.5) vs. No. 13 North Texas

No. 6 Texas Tech (-4, 132.5) vs. No. 11 Utah State

No. 3 Arkansas (-9.5, 157.5) vs. No. 14 Colgate

No. 7 Florida (PK) vs. No. 10 Virginia Tech

No. 2 Ohio State (-17, 154.5) vs. No. 15 Oral Roberts

 

MIDWEST REGION

No. 1 Illinois (-23, 144.5) vs. No. 16 Drexel

No. 8 Loyola-Chicago (-2, 127) vs. No. 9 Georgia Tech

No. 5 Tennessee (-8.5, 136) vs. No. 12 Oregon State

No. 4 Oklahoma State (-9.5, 146.5) vs. No. 13 Liberty

No. 6 San Diego State (-2, 137.5) vs. No. 11 Syracuse

No. 3 West Virginia (12, 138.5) vs. No. 14 Morehead State

No. 7 Clemson vs. No. 10 Rutgers (-1, 129)

No. 2 Houston (-18.5, 135.5) vs. No. 15 Cleveland State

 

Register with FanDuel Sportsbook and grab a $1,000 risk-free bet to commence your betting experience by clicking here.

 

March Madness Betting Trends

Now listen, predicting a bracket is indeed tough. Upsets occur, teams don’t show up as much as their opponents, and Cinderella stories shock the world. So when choosing your teams to win or betting on certain teams, there are a number of things to take into perspective.

What should help you out, however, is getting accustomed to different betting trends for the first round of the tournament.

Which trends should you keep in mind?

  • Take the 7-seeds to defeat the 10-seeds: It’s understandable if you think the “7 vs. 10” games are tough to predict and bet on — the seeds are close together and it’s not impossible for the 10-seed to come up big and pull off an upset en route to advancing to the second round. Nonetheless, the 7-seeded teams have historically been successful, having notched a record of 85-55 up to this point (60.7% winning percentage).
  • Hammer the spread for the underdogs when the 8-seed takes on the 9-seed: Likely the hardest games in the pick in the round of 64 is the “8 vs. 9” matchups. The difference in seeding can’t be any closer and either squad could be a tough matchup for the 1-seed they’ll probably play in the second round (barring a major upset in the “1 vs. 16” game). In these “8 vs. 9” matchups, the underdog has covered 59.1% of the time in the last 11 tournaments. The 9-seed, however, is 72-68 outright all-time against the 8-seed.
  • The first-round games provide a great deal of context for the eventual championship winner: In the last 18 tournaments, the eventual national champion has gone 14-4 against the spread in their first-round games. Thus, if you’re going to bet on a team to eventually win the title now, I’d wait until the round of 64 has concluded to do so.

 

2021 NCAA Tournament Winner Odds

As was previously mentioned, Gonzaga is the top team in the country and one of the No. 1 seeds in the tournament, so the Bulldogs possess great odds to win the Big Dance. However, Baylor is additionally a phenomenal program and teams like Michigan and Illinois will be in the mix. Alabama and Arkansas out of the SEC should make some noise as well.

Team Odds
Gonzaga +275
Baylor +300
Michigan +400
Illinois +800
Ohio State +1400
Iowa +1500
Oklahoma State +1600
Florida State +1600
Alabama +1600
Creighton +2000
Houston +2000
West Virginia +2000
Texas +2000
Kansas +2500
Virginia +2500
Villanova +2500
USC +2500
Texas Tech +2500
Wisconsin +2500
Tennessee +3500
UCLA +3500
Oklahoma +3500
Arkansas +4000
Loyola Chicago +4000
Oregon +5000
Florida +5000
North Carolina +5000
LSU +5000
Purdue +5000
UConn +5000
Virginia Tech +5000
Missouri +5000
Colorado +5000
Rutgers +5000
San Diego State +5000
Michigan State +6600
Utah State +6600
Syracuse +8000
BYU +8000
Clemson +8000
Oregon State +8000
Maryland +10000
Georgia Tech +10000
Wichita State +10000
Georgetown +10000
St. Bonaventure +10000
VCU +10000
Liberty +50000
North Texas +50000
Winthrop +50000
Ohio +50000
UNC Greensboro +50000
Iona +100000
Appalachian State +100000
Abilene Christian +100000
Cleveland State +100000
Colgate +100000
Drexel +100000
Eastern Washington +100000
Grand Canyon +100000
Hartford +100000
Morehead State +100000
Mount St. Mary’s +100000
Norfolk State +100000
Oral Roberts +100000
Texas Southern +100000
UC Santa Barbara +100000

 

Let’s take a look at the odds for the 2021 NCAA Tournament Winner.

 

Ryan is an experienced sports writer and editor, who's mainly covered the New York Giants and the NFL for Elite Sports NY.He additionally has his own podcast titled "Wide Right Podcast," which is available on all major platforms.