The College football betting season is in full swing and Week 3 is jam-packed with great games. Notre Dame is one of the biggest favorites of the week, opening as a 26-point favorite against South Florida.

The Fighting Irish began the season with a win against Duke on Saturday, but they couldn’t cover the 19.5-point spread. The Blue Devils hung around long enough to cover. Regardless, Notre Dame is 1-0 in ACC play and off on the right foot. The Irish are remaining independent, but they joined the ACC for one season following the news that the Big 10 and Pac-12 were canceling their seasons.

One of the better games of the week should be Miami vs. Louisville. This ACC matchup should be a bloodbath. The Cardinals open as 2-point favorites and the total points is set to 59.5. It should be a high-flying game with a lot of scoring and plenty of action to keep bettors interested.

Here is the full slate of college football Week 3 odds via DraftKings Sportsbook.

 

College Football Week 3 Schedule & Odds

Time Team Spread Total Money Line
12:00 PM Syracuse +21 -110 O 51.5 -110 +1100
12:00 PM Pittsburgh -21 -110 U 51.5 -110 -2500
12:00 PM Navy +8.5 -110 O 49 -110 +220
12:00 PM Tulane -8.5 -110 U 49 -110 -278
12:00 PM Baylor -7.5 -110 O 59 -110 -250
12:00 PM Houston +7.5 -110 U 59 -110 +200
12:00 PM Boston College +6 -110 O 50.5 -110 +185
12:00 PM Duke -6 -110 U 50.5 -110 -230
12:00 PM Louisiana-Lafayette -17.5 -110 O 61 -110 -1000
12:00 PM Georgia State +17.5 -110 U 61 -110 +600
12:00 PM Liberty +13 -110 O 59.5 -110 +310
12:00 PM Western Kentucky -13 -110 U 59.5 -110 -400
1:00 PM Southern Mississippi -3.5 -110 O 54.5 -110 -152
1:00 PM Louisiana Tech +3.5 -110 U 54.5 -110 +125
1:30 PM Appalachian State -3.5 -110 O 57 -110 -175
1:30 PM Marshall +3.5 -110 U 57 -110 +143
2:30 PM South Florida +26 -110 O 52.5 -110  
2:30 PM Notre Dame -26 -110 U 52.5 -110  
3:30 PM Charlotte +28 -110 O 61.5 -110 +1500
3:30 PM North Carolina -28 -110 U 61.5 -110 -5000
3:30 PM UCF -7.5 -110 O 60.5 -110 -278
3:30 PM Georgia Tech +7.5 -110 U 60.5 -110 +220
3:30 PM Florida Atlantic -7 -110 O 50.5 -110 -275
3:30 PM Georgia Southern +7 -110 U 50.5 -110 +215
4:00 PM Troy -3 -110 O 64 -110 -157
4:00 PM Middle Tennessee +3 -110 U 64 -110 +128
6:00 PM Tulsa +23.5 -110 O 65.5 -110 +1000
6:00 PM Oklahoma State -23.5 -110 U 65.5 -110 -2000
6:00 PM SMU -14 -110 O 66.5 -110 -530
6:00 PM North Texas +14 -110 U 66.5 -110 +390
7:30 PM Miami Florida +2 -110 O 59.5 -110 +110
7:30 PM Louisville -2 -110 U 59.5 -110 -134
7:30 PM Texas State -2 -110 O 60 -110 -134
7:30 PM Louisiana-Monroe +2 -110 U 60 -110 +110
8:00 PM Wake Forest +2.5 -110 O 56 -110 +118
8:00 PM NC State -2.5 -110 U 56 -110 -143