Last Updated on September 14, 2020

The College football betting season is in full swing and Week 3 is jam-packed with great games. Notre Dame is one of the biggest favorites of the week, opening as a 26-point favorite against South Florida.
The Fighting Irish began the season with a win against Duke on Saturday, but they couldn’t cover the 19.5-point spread. The Blue Devils hung around long enough to cover. Regardless, Notre Dame is 1-0 in ACC play and off on the right foot. The Irish are remaining independent, but they joined the ACC for one season following the news that the Big 10 and Pac-12 were canceling their seasons.
One of the better games of the week should be Miami vs. Louisville. This ACC matchup should be a bloodbath. The Cardinals open as 2-point favorites and the total points is set to 59.5. It should be a high-flying game with a lot of scoring and plenty of action to keep bettors interested.
Here is the full slate of college football Week 3 odds via DraftKings Sportsbook.
College Football Week 3 Schedule & Odds
Time | Team | Spread | Total | Money Line |
---|---|---|---|---|
12:00 PM | Syracuse | +21 -110 | O 51.5 -110 | +1100 |
12:00 PM | Pittsburgh | -21 -110 | U 51.5 -110 | -2500 |
12:00 PM | Navy | +8.5 -110 | O 49 -110 | +220 |
12:00 PM | Tulane | -8.5 -110 | U 49 -110 | -278 |
12:00 PM | Baylor | -7.5 -110 | O 59 -110 | -250 |
12:00 PM | Houston | +7.5 -110 | U 59 -110 | +200 |
12:00 PM | Boston College | +6 -110 | O 50.5 -110 | +185 |
12:00 PM | Duke | -6 -110 | U 50.5 -110 | -230 |
12:00 PM | Louisiana-Lafayette | -17.5 -110 | O 61 -110 | -1000 |
12:00 PM | Georgia State | +17.5 -110 | U 61 -110 | +600 |
12:00 PM | Liberty | +13 -110 | O 59.5 -110 | +310 |
12:00 PM | Western Kentucky | -13 -110 | U 59.5 -110 | -400 |
1:00 PM | Southern Mississippi | -3.5 -110 | O 54.5 -110 | -152 |
1:00 PM | Louisiana Tech | +3.5 -110 | U 54.5 -110 | +125 |
1:30 PM | Appalachian State | -3.5 -110 | O 57 -110 | -175 |
1:30 PM | Marshall | +3.5 -110 | U 57 -110 | +143 |
2:30 PM | South Florida | +26 -110 | O 52.5 -110 | |
2:30 PM | Notre Dame | -26 -110 | U 52.5 -110 | |
3:30 PM | Charlotte | +28 -110 | O 61.5 -110 | +1500 |
3:30 PM | North Carolina | -28 -110 | U 61.5 -110 | -5000 |
3:30 PM | UCF | -7.5 -110 | O 60.5 -110 | -278 |
3:30 PM | Georgia Tech | +7.5 -110 | U 60.5 -110 | +220 |
3:30 PM | Florida Atlantic | -7 -110 | O 50.5 -110 | -275 |
3:30 PM | Georgia Southern | +7 -110 | U 50.5 -110 | +215 |
4:00 PM | Troy | -3 -110 | O 64 -110 | -157 |
4:00 PM | Middle Tennessee | +3 -110 | U 64 -110 | +128 |
6:00 PM | Tulsa | +23.5 -110 | O 65.5 -110 | +1000 |
6:00 PM | Oklahoma State | -23.5 -110 | U 65.5 -110 | -2000 |
6:00 PM | SMU | -14 -110 | O 66.5 -110 | -530 |
6:00 PM | North Texas | +14 -110 | U 66.5 -110 | +390 |
7:30 PM | Miami Florida | +2 -110 | O 59.5 -110 | +110 |
7:30 PM | Louisville | -2 -110 | U 59.5 -110 | -134 |
7:30 PM | Texas State | -2 -110 | O 60 -110 | -134 |
7:30 PM | Louisiana-Monroe | +2 -110 | U 60 -110 | +110 |
8:00 PM | Wake Forest | +2.5 -110 | O 56 -110 | +118 |
8:00 PM | NC State | -2.5 -110 | U 56 -110 | -143 |
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