Last Updated on April 14, 2021

  • Trevor Lawrence and Zach Wilson are basically solidified as the respective top two picks
  • Mac Jones is favored to go to the 49ers as the No. 3 overall pick
  • The 2021 NFL Draft will commence with its opening round on Thursday, April 29



The 2021 NFL Draft is quickly approaching. Later this month — Thursday, April 29 to be exact — the Jacksonville Jaguars will be on the clock with the No. 1 overall pick and will surely select Clemson quarterback Trevor Lawrence. After that comes the Jets at No. 2, and following the recent trade of Sam Darnold to Carolina, it’s clear they will select BYU quarterback Zach Wilson.

Thus, the draft truly starts at No. 3 with the 49ers, and thanks to William Hill Sportsbook, there are a number NFL draft betting opportunities that could make you a winner.


No. 3 Overall Pick

Mac Jones:    -225

Justin Fields:  +250

Trey Lance:    +275

Zach Wilson: +1500

Kyle Pitts:    +1500

Ja’Marr Chase:  +6000

Penei Sewell: +8000


First Defensive Lineman Picked

Kwity Paye:  EVEN

Jaelan Phillips:   +160

Jayson Oweh: +750

Gregory Rousseau: +750

Christian Barmore: +800

Ronnie Perkins: +2500


First Defensive Player Picked

Micah Parsons: +110

Patrick Surtain II: +175

Kwity Paye: +550

Jaycee Horn: +900

Jaelan Phillips: +1200

Caleb Farley: +2500

Gregory Rousseau: +2500

Jeremiah Owusu-Koramoah: +4000


First Linebacker Picked

Micah Parsons: -400

Jeremiah Owusu-Koramoah: +650

Azeez Ojulari: +1000

Jamin Davis: +1000

Zaven Collins: +1800


First Running Back Taken:

Najee Harris: -150

Travis Etienne: +180


First Cornerback Taken:

Patrick Surtain II: -325

Jaycee Horn: +350

Caleb Farley: +800

Eric Stokes: +2500

Greg Newsome: +2500


First Wide Receiver Picked

Ja’Marr Chase: -500

DeVonta Smith: +400

Jaylen Waddle: +600


First Non-Quarterback Taken

Kyle Pitts: +140

Penei Sewell: +150

Ja’Marr Chase: +250

Rashawn Slater: +2500

Patrick Surtain II: +2000


Following the 49ers’ trade of numerous draft picks to move up to No. 3, it’s clear they will take a quarterback with the prestigious selection. Signs are pointing towards Alabama quarterback Mac Jones being the guy, and many would disagree with that type of pick given his lack of mobility and athleticism in comparison to some of the other quarterback prospects.



Kyle Pitts will likely be a top-10 pick in this draft, but it’s unclear if he’ll truly be the first non-quarterback taken. If the first four picks (Jaguars, Jets, 49ers, and Falcons) are quarterbacks, then Oregon offensive tackle Penei Sewell could be the first non-quarterback (many believe he could go No. 5 to the Bengals).

Rashawn Slater and Patrick Surtain are both longshots to be the first non-quarterback selected.

In regard to the running backs, Alabama’s Najee Harris could be off the board in the first round while Clemson’s Travis Etienne may drop to the early portion of the second. Mel Kiper of ESPN has Etienne going No. 34 overall to the Jets.



The linebacker position seems set with Penn State’s Micah Parsons projected to be the first one off the board, but Notre Dame’s Jeremiah Owusu-Koramoah may not be too far behind him. If the former goes in the top 10, there’s a chance the latter might go to the Giants at No. 11.


Place your wagers on multiple 2021 NFL Draft prop bets at William Hill Sportsbook by clicking here.