Last Updated on September 7, 2021
One thing is true when it comes to legal sports betting. It is always football season. That rings true as DraftKings Sportsbook and many others have released early Week 1 betting lines for the NFL season, which means that football betting is officially here for the regular season. You can wager on each and every game in Week 1, and attempt to beat the closing line before kickoff.
Let’s take a look at the Week 1 NFL odds, as sportsbooks have released spreads, totals, and moneylines for each game in Week 1. Below we show the odds, a look at Cowboys vs. Buccaneers, and our early picks for Week 1 of the NFL season.
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Live NFL Week 1 Odds
Here’s a look at the live odds for week 1 from various legal sportsbooks.
Week 1 NFL Public Betting Info
A look at the Week 1 public betting consensus from DraftKings Sportsbook.
| NFL Week 1 Splits | |||||||||
| Thursday, September 9, 2021 | |||||||||
| Teams | Spread | % Handle | % Bets | Total Points | % Handle | % Bets | Moneyline | % Handle | % Bets |
| DAL Cowboys | +7.5 | 14% | 15% | Over 49.0 | 33% | 46% | +280 | 53% | 19% |
| TB Buccaneers | -7.5 | 86% | 85% | Under 49.0 | 67% | 54% | -365 | 47% | 81% |
| Sunday, September 12, 2021 | |||||||||
| Teams | Spread | % Handle | % Bets | Total Points | % Handle | % Bets | Moneyline | % Handle | % Bets |
| ARI Cardinals | +3 | 7% | 16% | Over 51.5 | 73% | 61% | +140 | 69% | 24% |
| TEN Titans | -3 | 93% | 84% | Under 51.5 | 27% | 39% | -160 | 31% | 76% |
| JAX Jaguars | -3 | 84% | 85% | Over 45.5 | 14% | 39% | -160 | 89% | 73% |
| HOU Texans | +3 | 16% | 15% | Under 45.5 | 86% | 61% | +140 | 11% | 27% |
| LA Chargers | -1 | 76% | 70% | Over 44.0 | 68% | 61% | -120 | 49% | 50% |
| WAS Football Team | +1 | 24% | 30% | Under 44.0 | 32% | 39% | +100 | 51% | 50% |
| MIN Vikings | -3.5 | 82% | 60% | Over 48.0 | 26% | 49% | -195 | 35% | 66% |
| CIN Bengals | +3.5 | 18% | 40% | Under 48.0 | 74% | 51% | +165 | 65% | 34% |
| NY Jets | +5 | 32% | 28% | Over 43.0 | 93% | 47% | +190 | 59% | 19% |
| CAR Panthers | -5 | 68% | 72% | Under 43.0 | 7% | 53% | -235 | 41% | 81% |
| PHI Eagles | +3.5 | 59% | 52% | Over 48.0 | 59% | 64% | +175 | 96% | 47% |
| ATL Falcons | -3.5 | 41% | 48% | Under 48.0 | 41% | 36% | -210 | 4% | 53% |
| PIT Steelers | +6.5 | 20% | 37% | Over 50.0 | 31% | 33% | +260 | 71% | 21% |
| BUF Bills | -6.5 | 80% | 63% | Under 50.0 | 69% | 67% | -335 | 29% | 79% |
| SEA Seahawks | -1.5 | 88% | 74% | Over 48.5 | 55% | 42% | -130 | 67% | 86% |
| IND Colts | +1.5 | 12% | 26% | Under 48.5 | 45% | 58% | +110 | 33% | 14% |
| SF 49ers | -7.5 | 69% | 69% | Over 45.5 | 42% | 44% | -380 | 69% | 84% |
| DET Lions | +7.5 | 31% | 31% | Under 45.5 | 58% | 56% | +290 | 31% | 16% |
| CLE Browns | +6.5 | 22% | 28% | Over 53.0 | 73% | 47% | +220 | 61% | 12% |
| KC Chiefs | -6.5 | 78% | 72% | Under 53.0 | 27% | 53% | -275 | 39% | 88% |
| DEN Broncos | -2 | 71% | 63% | Over 42.5 | 33% | 50% | -135 | 18% | 46% |
| NY Giants | +2 | 29% | 37% | Under 42.5 | 67% | 50% | +115 | 82% | 54% |
| GB Packers | -3 | 89% | 91% | Over 50.0 | 40% | 33% | -165 | 96% | 83% |
| NO Saints | +3 | 11% | 9% | Under 50.0 | 60% | 67% | +145 | 4% | 17% |
| MIA Dolphins | +3 | 10% | 34% | Over 44.5 | 13% | 33% | +140 | 51% | 51% |
| NE Patriots | -3 | 90% | 66% | Under 44.5 | 87% | 67% | -160 | 49% | 49% |
| CHI Bears | +7 | 30% | 20% | Over 45.0 | 10% | 78% | +290 | 58% | 13% |
| LA Rams | -7 | 70% | 80% | Under 45.0 | 90% | 22% | -380 | 42% | 87% |
| Monday Night Football Splits | |||||||||
| Teams | Spread | % Handle | % Bets | Total Points | % Handle | % Bets | Moneyline | % Handle | % Bets |
| BAL Ravens | -4.5 | 81% | 89% | Over 51.0 | 60% | 46% | -250 | 69% | 87% |
| LV Raiders | +4.5 | 19% | 11% | Under 51.0 | 40% | 54% | +200 | 31% | 13% |
| Provided by DraftKings Sportsbook | |||||||||
For Cowboys vs. Bucs in Week 1, each sportsbook has either -6.5 or -6 as the spread, favoring the Super Bowl champion Tampa Bay Buccaneers. Getting the best number (Bucs -6 at FanDuel Sportsbook) will be key as you shop for value for the first week of the NFL season, albeit months away.
Keep an eye on the NFL public betting consensus, as NFL bettors will always pounce on early lines.
NFL Week 1 betting (@BetMGM)
Most bet games (ticket count)
• Titans-Cardinals
• Chiefs-Browns
• Jets-PanthersLine movement
• MIN -2.5 to -3
• SF -7 to -7.5
• JAX -1.5 to -2.5
• KC -5.5 to -6
• NE -2 to -2.5
• LAC +1 to -1
• NYJ +4.5 to +4
• LVv+5.5 to +4.5— John Ewing 🦁 (@johnewing) May 13, 2021
Odds Movement for NFL Week 1 Spreads
With the NFL season rapidly approaching as training camp opens, the odds for Week 1 have already shifted. Most importantly, here is a look at which games have shown significant odds movement for Week 1.
| Opening Spread | Current Spread |
| Dallas Cowboys at Tampa Bay Buccaneers (-6.5) | Cowboys at Buccaneers (-6) |
| Los Angeles Chargers (-1.5) at Washington Football Team | Chargers at Football Team (-1) |
| Minnesota Vikings (-3.5) at Cincinnati Bengals | Vikings (-3) at Bengals |
| Seattle Seahawks at Indianapolis Colts (-2.5) | Seahawks (-3) at Colts |
| Denver Broncos (-1.5) at New York Giants | Broncos (-1) at Giants |
| Green Bay Packers at New Orleans Saints (-2.5) | Packers (-2.5) at Saints |
As you can see, six games have changed from the opening lines on DraftKings Sportsbook. Each games’ odds movement looks as follows:
- Tampa Bay Buccaneers (-6.5 to -6)
- Washington Football Team (+1 to -1)
- Minnesota Vikings (-3.5 to -3)
- Seattle Seahawks (+2.5 to -3)
- Denver Broncos (-1.5 to -1)
- Green Bay Packers (+2.5 to -2.5)
Both teams with the largest movement, Packers and Seahawks, saw movement due to the quarterback situations. The Packers moved five total points as Aaron Rodgers is ready to go for Week 1, along with Davante Adams. As for the Seahawks, they moved a total of 5.5 points given the injury to Carson Wentz. The Colts lost Wentz for Week 1, and will likely be without Quenton Nelson as well. Five-point moves are rare, but we saw two of them for Week 1 this year.
Top NFL Week 1 Games to bet on
After the opening lines were released, NFL bettors immediately set their sights on the top games for Week 1. While NFL public betting information will be available closer to the start of Week 1, it is still quite easy to tell which games are set to have the heaviest handle in terms of dollars wagered on the game. Here are the top 5 games to bet on in Week 1.
1. New York Jets at Carolina Panthers Week 1 Odds
All Jets fans have been waiting for is happening right away in Week 1. Jets’ rookie quarterback Zach Wilson will make his NFL debut against Sam Darnold, the Jets’ former quarterback in a battle of young QBs looking to take the next step in their NFL careers. The Panthers open as -4.5-point favorites with the total being a low 43-points.
- Spread: Panthers (-4.5)
- Total: 43
- Moneyline: Panthers -200, Jets +160
Zach Wilson on #Jets' Week 1 matchup vs. Panthers/Darnold:
"My first reaction was: Just typical NFL, right? I mean, they love it. They love to bring the fans & I love it. I mean, what an exciting matchup it's going to be for us. I'm excited to be able to play them."
— Dennis Waszak Jr. (@DWAZ73) May 27, 2021
2. Pittsburgh Steelers at Buffalo Bills Week 1 Odds
This potential AFC playoffs matchup between the Steelers and Bills will be one for the ages, as one of the best offenses and best defenses in the NFL face off against each other in Week 1. Betting on the over seems to be the lean so far, as the opening total is over seven touchdowns at 50 points. Here is a look at the opening odds.
- Spread: Bills (-6.5)
- Total: 50 points
- Moneyline: Bills -278, Steelers +220
David Carr (plenty of concussions) says the #Steelers will be "rolled out" by the Bills during week 1. Says Josh Allen will have fun against the Steelers Defense…
— SteelerNation (@SteeIerNation) June 10, 2021
3. Denver Broncos at New York Giants Week 1 Odds
Two very popular teams when it comes to sports betting are the Broncos and the Giants. While neither may be a title contender, both teams are located in or near legal sports betting states with fans that love to wager on either side. This makes for a terrific game to watch when it comes to public betting percentages, as the public may heavily wager on one side. This is a great time to take advantage of the public with local bias and capture a winning wager. Here are the DraftKings odds.
- Spread: Broncos (-1.5)
- Total: 42.5 points
- Moneyline: Broncos -117, Giants -105
For a team that is 0-7 in the last two Septembers, the Broncos’ early schedule couldn’t have fallen much better. After the Week 1 opener at the Giants (6-10 in ‘20), Denver faces the two worst teams in football last year (Jags, Jets). Anything less than 2-1 would be a problem.
— Nick Kosmider (@NickKosmider) May 13, 2021
4. Cleveland Browns at Kansas City Chiefs Week 1 Odds
The best team in the NFL is often one of the most popular to wager on, and the Chiefs have been thought of as the best team in football despite losing in the Super Bowl last year. This could very well be an AFC Championship preview between the Browns and Chiefs, which makes it quite the popular game for sports bettors. Here’s a look at the odds.
- Spread: Chiefs (-6)
- Total: 52.5 points
- Moneyline: Chiefs -275, Browns +215
.@FOXBet makes Patrick Mahomes and the Chiefs a 6-point favorite in Week 1 against the Browns, are they too big of a favorite?@ClayTravis explains why this is too many points: pic.twitter.com/62iDYpib9N
— FOX Bet Live (@FOXBetLive) May 14, 2021
5. Green Bay Packers at New Orleans Saints Week 1 Odds
In what may be the NFC game of the week when the time comes, the Packers and Saints have been two of the best teams in the NFC for the better part of a decade. With Drew Brees retiring and Aaron Rodgers on the fence in Green Bay, could we see Taysom Hill/Jameis Winston vs. Jordan Love in this game? Expect bettors to be all over the Saints if Rodgers leaves, but there is some value if you believe the Packers and Aaron Rodgers make up and he remains Green Bay’s quarterback.
- Spread: Saints (-2.5)
- Total: Off the board
- Moneyline: Saints -137, Packers +112
Saints vs Packers in the Dome for Week 1 🙌
⚜️ Full #Saints schedule will be posted on https://t.co/KlYFEtTVGF at 6:45 pm CT
⚜️ @NFLNetwork's Schedule Release show at 7 pm CT pic.twitter.com/LCzSvIfevn
— New Orleans Saints (@Saints) May 12, 2021
Week 1 Opening Lines – NFL 2021
A look at each Week 1 matchup, with opening odds courtesy of DraftKings Sportsbook.
- Dallas Cowboys at Tampa Bay Buccaneers (-6.5)
- Los Angeles Chargers (-1.5) at Washington Football Team
- San Francisco 49ers (-7.5) at Detroit Lions
- Jacksonville Jaguars (-2.5) at Houston Texas
- Minnesota Vikings (-3.5) at Cincinnati Bengals
- Arizona Cardinals at Tennessee Titans (-2.5)
- Seattle Seahawks at Indianapolis Colts (-2.5)
- Philadelphia Eagles at Atlanta Falcons (-3.5)
- New York Jets at Carolina Panthers (-4.5)
- Pittsburgh Steelers at Buffalo Bills (-6.5)
- Denver Broncos (-1.5) at New York Giants
- Miami Dolphins at New England Patriots (-2)
- Clevland Browns at Kansas City Chiefs (-6)
- Green Bay Packers at New Orleans Saints (-2.5)
- Chicago Bears at Los Angeles Rams (-7)
- Baltimore Ravens (-4.5) at Las Vegas Raiders
Cowboys vs. Buccaneers NFL Week 1
The first game of the season is Thursday Night Football, a matchup between the Dallas Cowboys and the Tampa Bay Buccaneers. Of course, the Bucs are reigning Super Bowl champions, but the Dallas Cowboys are returning their quarterback in Dak Prescott and a revamped defense from the offseason, including the NFL Draft. Here is a look at the opening odds.
| Team | Spread | Total | Moneyline |
| Dallas Cowboys | +6.5 | o52.5 | +220 |
| Tampa Bay Buccaneers | -6.5 | u52.5 | -278 |
Tampa is favored by 6.5, with the total at a high 52.5 points. With the Bucs bringing back literally every member of the Super Bowl team, 6.5 points at home seems like a bargain. Expect this line to move towards Tampa Bay as the offseason progresses. After all, they did just win the big one.
NFL Week 1 Betting Picks
It is never too early for NFL Week 1 betting picks, and given that many legal sportsbooks have the three main markets available: spreads, totals, and moneylines, here are our picks for Week 1.
Top 5 NFL Week 1 Bets
Our five favorite bets for Week 1 of the 2021 NFL season, odds are current as of
- Tampa Bay Bucs -6.5 (-108 at DraftKings)
- Eagles vs. Falcons OVER 46.5 (-115 at William Hill)
- Bills -6 vs. Steelers (-110 at PointsBet)
- Colts -2 vs. Seahawks (-110) at FanDuel
- Jaguars -1.5 vs. Texans (-109) at DraftKings
Looking for more NFL betting action? Check out the latest NFL rookie betting props and the 2022 NFL Draft first overall pick odds.
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