Last Updated on September 13, 2020

The betting frenzy of NFL Week 1 lines is in progress and the two most popular games might surprise you. On William Hill Sportsbook, the two games that are garnering the most attention from the public are Arizona Cardinals vs. San Francisco 49ers and Tampa Bay Buccaneers vs. New Orleans Saints. Both of these games will take place during the 4 o’clock slate of games.

The Cardinals, Buccaneers, and Green Bay Packers are the only three underdogs who are bringing in a majority of bet tickets placed on their games. A quick side note on Wiliam Hill, they just expanded their sportsbook app access to the Illinois sports betting market. You can see our full update and review for William Hill Illinois.


Dog Cardinals Getting Public Love vs. 49ers

The Cardinals-49ers game is somewhat surprising, but the emergence of Kyler Murray and the trade for DeAndre Hopkins are potential reasons for the widespread interest in the Cardinals. A sizable chunk of the money on this game is coming in on the Cardinals.

“I think it’s a lot of factors for why Arizona is getting this much action,” Bogdanovich said. “Year 2 of Kyler Murray, everyone’s thinking he’s gonna have a breakout season. They got DeAndre Hopkins. San Francisco’s a little banged up with their receivers. These two teams know each other well, and Arizona has hung with them the past couple seasons.”

There are some big-money bets coming in on Arizona so it’s no surprise that they account for 83% of all money laid on this game. William Hill Nevada took a $30,000 spread line bet on the Cardinals which is the largest spread wager the sportsbook has taken so far this weekend.

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Brady’s Bucs vs. Saints Seeing Big Bets

As to why bettors are so interested in Bucs-Saints, look no further than Tom Brady. The future Hall of Famer is going to be taking his first snaps for Tampa Bay and the interest-level is at an all-time high. Everyone wants to see how Brady performs outside of New England and without his longtime head coach Bill Belichick.

Of course, it certainly helps that Brady is going against another all-time great quarterback in Drew Brees. Brady and Brees have had some great battles over the years, but this will be the first time they ever square off as division rivals. The action is split fairly evenly between the two teams with 58% of bet tickets coming in on the Bucs, but 55% of the money going towards the Saints.


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