Last Updated on November 16, 2020

  • The Ohio State Buckeyes are -20.5 against the Indiana Hoosiers this weekend. The total is set to 63.5.
  • Indiana is 4-0 against the spread this season.
  • Justin Fields is a co-favorite to win the Heisman Trophy.
  • Ohio State is on a 24-game winning streak against Indiana.


The Indiana Hoosiers are surging to the top of the Big Ten standings, but in order to be the best, they have to beat the best. The Ohio State Buckeyes have long been the class of the conference and the Hoosiers will have their chance to make a statement this weekend.

The winner will have the inside track at a berth in the College Football Playoff and potentially a National Championship. The loser will face an uphill battle in this coronavirus-shortened season.

No. 3 Ohio State vs. No. 9 Indiana is the marquee game of Week 12 of the college football season. Let’s take a look at the best odds, lines, analysis, and everything else you need to know for Ohio State vs. Indiana this week.


Ohio State – Indiana 2020 Line

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Ohio State is the massive favorite in this game despite the fact that Indiana is undefeated and made its way into the top 10 of the AP Poll. The Buckeyes opened at -20.5 on PointsBet Sportsbook, but there are some books that have them as high as -21.5. There aren’t many games between top 10 teams that are three-touchdown spreads, but here we are.

Anyone who thinks Indiana can pull off the upset can find good value on the moneyline. The Hoosiers are currently +710, which implies that they have approximately a 12% chance at winning. Ohio State has bulldozed its way to three wins so far this year, but Indiana continues to surprise everyone.

The total is set to 63.5.


Preview and Betting Angles

This is the biggest football game for Indiana in decades. A win would give the Hoosiers another huge win for their College Football Playoff resumé and it would put them in prime position to make the Big Ten Championship Game. In fact, the loser of this game will need a ton of help to even have a shot at the College Football Playoff.

The Buckeyes are led by Heisman Trophy hopeful Justin Fields. The junior quarterback is one of the co-favorites to win the award along with Trevor Lawrence, Kyle Trask, and Mac Jones. This game is a huge opportunity for Fields to make a statement on a big stage. In three games for Fields so far in 2020, he has as many touchdowns (11) as he does incompletions. It’s hard to play at a higher level than he is right now.

Ohio State is averaging more than 500 yards per game this season, but Indiana’s defense has been excellent at keeping teams out of the endzone. The Hoosiers are only allowing 19.3 points per game this year. Ohio State will be able to move the football down the field, but if Indiana can play bend, but don’t break defense, they will give themselves a chance.

Indiana quarterback Michael Penix Jr. can hold his own against anybody in college football. Penix has 11 total touchdowns and just three interceptions on the season. His heroic effort against Penn State in the season opener was one of the great moments of the college football season so far. Does he have any more magic in his arm and legs?

We expect both teams to put up some points on Saturday, but 63.5 is an awfully high number to hit, even in today’s high-scoring version of college football. Indiana is 3-1 on over-unders while Ohio State is 1-1-1.

When it comes to covering the spread, no team has been more successful than Indiana in 2020. The Hoosiers are 4-0 against the spread and this will be the third time all year that they are the underdog. Of course, this is the biggest spread Indiana will face likely all season.


Ohio State vs. Indiana History

This historical matchup is as lopsided as you will find in college football. The Buckeyes hold the all-time advantage over the Hoosiers 75-12-5. The Buckeyes are on a 24-game winning streak against the Hoosiers. In fact, 1988 was the last time Indiana beat Ohio State and 1987 was the last time they did it in Columbus.

Indiana took a beating at home against Ohio State last year, losing 51-10 in a game that was a complete blowout.


How To Watch Ohio State vs. Indiana

  • Date: Saturday, Nov. 21
  • Time: 12:00 p.m. ET
  • Location: Ohio Stadium (Columbus, Ohio)
  • TV: FOX


Betting Picks and Score Prediction

This will be the biggest test of the year for Indiana and although we don’t expect them to come away with the win, this won’t be a three-score blowout like the spread would suggest. The Hoosiers will hang around with the Buckeyes for long enough to cover this ridiculous three-touchdown spread. Take Indiana with the points.

This has the potential to go over as well, but the safer play is to take Indiana and hope that this is a close game going into the fourth quarter.

Score Prediction: Ohio State wins 37-27