Last Updated on March 28, 2021

  • The USC Trojans are -2 on the spread line against the Oregon Ducks in the Sweet 16. The total is set to 138 points.
  • Oregon is 13-11 against the spread in 2020-21. USC is 16-12.
  • USC beat Oregon 72-58 in their only other meeting this year.

The Pac-12, or the “Conference of Champions” as Bill Walton prefers to call it, has a fantastic matchup in the Sweet 16. USC and Oregon will meet for the chance to advance to the Elite Eight and likely face Gonzaga. This is a can’t-miss college basketball game.

The Action Rush NCAA Tournament betting guide has the best odds, analysis, and everything else you need to know for Oregon vs. USC in the Sweet 16 of the NCAA Tournament.


Oregon vs. USC Betting Odds Sweet 16

[metabet_core_game_tile query=”cbb/oregon” site_id=”actionrush”]


Oregon Ducks +110 +2 (-114) 138 (Ov-10)9
USC Trojans -130 -2 (-106) 138 (Un-110)

USC is -2 on the spread line against Oregon at most online sportsbooks. We always recommend doing your research to find the best lines, but this one is more or less the same at most online sportsbooks. The Trojans are -130 on the moneyline and compared to Oregon at +110. The total points are set to 138.

Oregon is 13-11 against the spread this year. Meanwhile, USC is 16-12 ATS in 2020-21. Both teams covered their first and second round games in the NCAA Tournament. USC beat Oregon by 14 in their only other meeting this season. The Trojans were -3 on the spread line in that game.


Who is the public betting on?

Here are the public betting picks for Sunday’s games at DraftKings Sportsbook:

Sunday, March 28, 2021
Teams Point Spread % Handle % Bets Total Points % Handle % Bets Moneyline % Handle % Bets
#5 Creighton +13.5 29% 28% Over 158.0 67% 55% +700 50% 27%
#1 Gonzaga -13.5 71% 72% Under 158.0 33% 45% -1115 50% 73%
#4 Florida State +2.5 37% 39% Over 144.0 27% 45% +118 42% 45%
#1 Michigan -2.5 63% 61% Under 144.0 73% 55% -139 58% 55%
#11 UCLA +6.5 32% 36% Over 145.5 80% 77% +215 35% 31%
#2 Alabama -6.5 68% 64% Under 145.5 20% 23% -265 65% 69%
#7 Oregon +2 35% 38% Over 138.5 60% 82% +112 52% 60%
#6 USC -2 65% 62% Under 138.5 40% 18% -132 48% 40%
Provided by DraftKings Sportsbook


Game Breakdown

This is a matchup between two teams that know each other very well. Andy Enfield and Dana Altman have been at their schools for a number of years and even though the personnel changes, their styles stay the same year in and year out.

Oregon is one of the toughest teams left in the NCAA Tournament field. They play hard-nosed defense with All-American guard Chris Duarte leading the way. Their ball pressure confounded Iowa in the second round. However, don’t pigeonhole the Ducks as a defensive-minded team — they can score with anyone in the country.

As for USC, they are led by a dynamic duo in Evan Mobley and Isaiah Mobley. Evan is likely going to end up as a top-three pick in the upcoming draft and Isaiah is no slouch either. The brothers combined for 27 points, 21 rebounds, and nine assists in their blowout victory over Kansas in the second round.

Isaiah didn’t even play in USC’s first meeting with the Ducks this season. The Trojans won that game by 15 as Tahj Eddy went off for 24 points on 6-for-11 shooting. This game is a toss-up that could go either way, but USC has the slight edge.


Oregon & USC Futures Odds

To Win The Championship:
USC +2500
Oregon +4000

To Win The West Region:
USC +600
Oregon +700

USC To Make The Elite Eight:
Yes +600
No -1000

Oregon To Make The Final Four:
Yes +700
No -1250

Pick: USC Sneaks Past Oregon

Oregon has looked fantastic to this point in the NCAA Tournament, but we are having a tough time betting against the Trojans. The Mobley brothers have too much talent to lose this game and with the spread at such a reasonable number, it makes sense to take the Trojans here.

The Pick: USC -2

Final Score Prediction: USC wins 69-65